Atherosclerotic plaque rupture: an overview
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منابع مشابه
Atherosclerosis and Atheroma Plaque Rupture: Imaging Modalities in the Visualization of Vasa Vasorum and Atherosclerotic Plaques
Invasive angiography has been widely accepted as the gold standard to diagnose cardiovascular pathologies. Despite its superior resolution of demonstrating atherosclerotic plaque in terms of degree of lumen stenosis, the morphological assessment for the plaque is insufficient for the analysis of plaque components, and therefore, unable to predict the risk status or vulnerability of atherosclero...
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In MI there is a decrease in coronary flow or an equivalent abrupt increase in myocardial demand for oxygen due to ischemic necrosis caused by obstruction in the coronary artery. Thrombus or atherosclerotic plaque may obstruct the coronary flow. The atherosclerotic lesion contain macrophage and activated T-cells which secrete cytokines . This inflammatory response results in plaque rupture and ...
متن کاملMouse model for atherosclerotic plaque rupture.
Rupture of advanced human atherosclerotic plaques can precipitate coronary thrombosis, myocardial infarction, and sudden death, but insights into the causes and treatment of plaque rupture have been hampered by lack of a suitable animal model. Particularly desirable would be a model of plaque rupture that would take advantage of current and forthcoming mouse mutant alleles. It is therefore of c...
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OBJECTIVE Lysosomal proteinases have been implicated in a number of pathologies associated with extracellular matrix breakdown. Therefore, we investigated the possibility that the lysosomal proteinase cathepsin S may be involved in atherosclerotic plaque destabilization. METHODS AND RESULTS Atherosclerotic plaques in the brachiocephalic arteries of fat-fed apolipoprotein E/cathepsin S double ...
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Kumar A, Kar S, Fay WP. Thrombosis, physical activity, and acute coronary syndromes. J Appl Physiol 111: 599–605, 2011. First published May 19, 2011; doi:10.1152/japplphysiol.00017.2011.—Acute coronary syndromes (ACS) are common, life-threatening cardiac disorders that typically are triggered by rupture or erosion of an atherosclerotic plaque. Platelet deposition and activation of the blood coa...
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